Lecture Notes for Introduction to Biological Modeling Class 4: Gene regulatory networks

Genetic regulation Central dogma of molecular biology: DNA makes RNA makes protein. Gene regulatory data are primarily from ChIP-chip and ChIP-seq. BioTapestry is an interactive tool for building, visualizing, and simulating genetic regulatory networks. Hamid Bolouri, a Hutch member, is an author. Transcription factors bound to DNA perform transcription regulation Small RNAs: miRNA (micro RNA) performs translation regulation by degrading mRNA or by reducing its translation; siRNA (small interfering RNA) do the same, or do transcriptional silencing. Very few models account for small RNAs.